135 articles - From Friday Jun 06 2025 to Friday Jun 13 2025
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
| Gastroenterology |
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meta-analyses and systematic reviews
| Aliment Pharmacol Ther |
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Systematic Review: Use of Artificial Intelligence and Unmet Needs in Eosinophilic Oesophagitis. Although AI showed promise at improving EoE management across various domains, most tools require validation on larger, independent and prospective cohorts. Several challenges, including algorithmic bias, data privacy, explainability and regulatory hurdles, need to be addressed for clinical implementation. Future studies should focus on developing non-invasive diagnostic tools for younger populations, treatment response prediction and disease monitoring. |
| Am J Gastroenterol |
Global prevalence of celiac disease in patients with Rome III and Rome IV irritable bowel syndrome: A systematic review and meta-analysis. CeD is highly prevalent in patients with IBS, according to the Rome III and Rome IV criteria. A positive diagnosis of IBS should not be made without excluding CeD. |
Racial, Ethnic and Socioeconomic Disparities in Celiac Disease Trials: A Systematic Review of Participant Diversity and Trial Site Distribution. Despite efforts to improve minority inclusion in RCTs, significant disparities persist in CeD trials, with minimal racial and ethnic diversity. As demand for pharmacologic treatments grows, future trials must address these gaps through diverse recruitment, equitable site distribution, and targeted outreach to ensure emerging therapies are generalizable and accessible to al patients. |
The Safety of Pharmacotherapy for Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis. Among pharmacotherapies for IBS, tricyclics (especially at elevated doses), tenapanor, and alosetron have the highest absolute risk of discontinuation due to an AE when compared to rifaximin, the safest pharmacotherapy studied. |
| Endoscopy |
Comparison of the treatment of endo-vacuum therapy with standard care for colorectal anastomotic leakage: a systematic review and meta-analysis. This meta-analysis suggests that EVT has superior effectiveness in improving closure rates, as well as a shorter treatment duration compared to standard care for colorectal anastomotic leakage. However, this study is constrained by the lack of prospective data, the risk of selection bias and heterogeneity, requiring cautious interpretation of the findings. |
| Gastroenterology |
Glucagon-like peptide-1 Receptor Agonists and Gastrointestinal Adverse Events: a Systematic Review and Meta-analysis. GLP-1RAs are associated with an increased risk of cholelithiasis and GERD but do not appear to increase the risk of other gastrointestinal or biliary adverse events. |
RCT, clinical trials, retrospective studies, etc…
| Aliment Pharmacol Ther |
|---|
Breath Testing for Colorectal Cancer Detection in Patients With a Positive Fecal Immunochemical Test: A Multicentre Prospective Cross-Sectional Study With External Validation. Further research is needed to standardise and validate e-nose devices before supplementing current screening methods. Identifier NCT03346005 and NCT04357158. |
CD300A<sup>+</sup> CD8<sup>+</sup> T Cells as Predictive Biomarkers for Achieving Functional Cure in Chronic Hepatitis B Patients Undergoing Pegylated Interferon-Alpha Therapy. CD300A + CD8 + T cells are enriched in patients achieving FC during PEG-IFN-α therapy, exhibiting robust clonal expansion, enhanced cytotoxicity and HBV antigen specificity. These cells may serve as potential biomarkers for treatment response to improve FC rates in CHB therapy. |
Effects of Screening Colonoscopy on Colorectal Cancer Mortality: Lessons From Comparative Analyses of Randomised Trials. Other sigmoidoscopy trials yielded similar 11- to 12-year results. Our analysis suggests that the apparent negative CRC mortality results of NordICC primarily reflect insufficient follow-up time. |
Factors Associated With Underutilization of Antiviral Therapy in Preventing Hepatitis B Virus-Related Hepatocellular Carcinoma. Three-quarters of patients who developed HBV-related HCC had not received antiviral therapy before HCC diagnosis. These patients were characterised by a lower proportion of cirrhosis, infrequent clinical visits, fewer HBV evaluations, more advanced HCC stage, and poorer prognosis. |
Higher Prescribed Opioid Use Among Adults With Crohn's Disease Than General Population: A Nationwide Cohort Study in Sweden 2006-2021. Adults with incident CD had a two-fold higher use of dispensed opioids than references 2 years before diagnosis, which peaked at three- and four-fold higher use around diagnosis and remained high for 3-5 years. The decreased use of weak opioids might explain the recent decline in opioid consumption among patients with CD. |
Occurrence and Management of Opportunistic Infections in Patients With Autoimmune Hepatitis: A Spanish Multicentre Study. The occurrence of OI in AIH is very low, suggesting that LTBI screening and treatment may be unnecessary. In contrast, Aspergillus infection seems to be associated with acute severe AIH with dismal prognosis. |
Outcomes Associated With Anti-Depressant Use in Patients With Inflammatory Bowel Disease. Antidepressant use is associated with reduced ER utilisation in patients with IBD. There were also increased hospitalisations, corticosteroid treatment, and surgery, which may reflect a more aggressive disease course associated with depression. Treating depression in patients with IBD may reduce healthcare costs by decreasing ER visits. |
Predicting Hepatic Decompensation in Patients With Metabolic Dysfunction Associated Steatotic Liver Disease-Related Cirrhosis: The ABID-LSM Model. The ABID-LSM model has greater accuracy in predicting hepatic decompensation in patients with cirrhosis due to MASLD than existing predictive models. If externally validated, ABID-LSM may identify those who benefit from pharmacotherapy and close monitoring. |
| Am J Gastroenterol |
Association of GLP-1 Receptor Agonists with Liver-Related Outcomes and All-Cause Mortality in Patients with Harmful Alcohol Use: A Target Trial Emulation Study. and relevance In this observational target trial emulation study, GLP-1 RA use was associated with a lower risk of liver outcomes, death, and harmful alcohol use. |
Birth outcomes in women who have taken vedolizumab in pregnancy: results from the Vedolizumab Pregnancy Exposure Registry. No significant increased risks were noted with vedolizumab exposure for any of the other study outcomes. These data add reassuring evidence in support of the safety of vedolizumab in pregnancy. |
Cardiovascular risk assessment tools are insufficient for patients with metabolic dysfunction associated steatotic liver disease. Commonly used tools to identify CV risk performed poorly in a cohort of patients with MASLD. As CV related death is the greatest source of mortality among patients with MASLD, better risk assessment tools are required. |
DRESS syndrome in patients with drug-induced liver injury: Characteristics and HLA risk factors. Patients with DILI and DRESS are younger, more likely to be Black, had shorter time to DILI onset with more severe liver injury and higher overall and liver-related mortality. HLA A*32 01, HLA B*53 01 and HLA B*58 01 are risk factors for DILI-DRESS. |
Effectiveness and Safety of Advanced Combination Treatment (ACT) in patients with refractory inflammatory bowel disease or concomitant immune mediated disease or extra-intestinal manifestations: A Multi-Center Canadian Study. ACT was effective in achieving clinical and endoscopic outcomes in patients with refractory IBD or concomitant IMIDs/EIMs, with favorable safety profile. |
Evaluation of the PAN-PROMISE symptom scale in a randomized controlled trial of fluid resuscitation in acute pancreatitis. In the context of a RCT, the PAN-PROMISE score, a patient-centered measure, has been validated with established AP outcomes and as an endpoint for future clinical trials. |
Impact of MASLD and associated comorbidities on Cognitive and Health-related Quality of Life outcomes in a Mixed MASLD-T2DM Cohort. Our findings highlight the relationship between MASLD severity and impairment in cognitive function and HRQoL, underscoring its multifactorial nature. Specifically, severe hepatic steatosis may be a risk factor for cognitive decline, whereas significant or high liver stiffness appears to have a greater impact on HRQoL. |
Little Patients Big Discoveries: Potential Pediatric to Adult Neurogastroenterology Translation. To date, efficacy studies using auricular neurostimulation in adults with gastrointestinal disorders have not been performed. These areas highlight how pediatric neurogastroenterology generates discoveries with the potential to guide approaches in adult populations, underscoring the bidirectional value of translational clinical science. |
Monitoring Inflammatory Bowel Disease Activity: When, How and Why. In this review, we will discuss the different strategies for assessing disease activity and the timing of evaluation for each treatment target for outpatient IBD care. We will also highlight the role of radiographic assessment with a focus on intestinal ultrasound for monitoring these treatment endpoints. |
Optimizing the cost-effective evaluation of gastroesophageal reflux by typical symptom phenotypes after failure of empiric acid suppression trial. Compared to a one-size-fits-all strategy, a tailored approach based on Lyon 2.0 optimizes cost-effective evaluation and management of GERD by phenotyping the appropriate diagnostics to dominant symptom. |
Psychomotor speed from minimal hepatic encephalopathy testing is associated with physical frailty in patients with advanced chronic liver disease. The findings suggest that the LFI score in this population reflects its ability to capture the crucial role of psychomotor speed, particularly evident in off-time performance, thus connecting neurocognitive and physical function. Further research is warranted to investigate the effectiveness of interventions targeting cognitive and physical impairments to enhance clinical outcomes in patients with AdvCLD. |
Real-world experience of home continuous terlipressin infusion for complications of portal hypertension. This study demonstrates the safety of home CTI in a real-world cohort of over 100 well-selected transplant-eligible patients with decompensated cirrhosis. It confirms previous findings that long-term CTI is associated with increased HGS and reduced paracentesis, in addition to its established benefit on renal function. These data provide strong clinical rationale for further prospective randomized trials to investigate the use of CTI as a bridge to liver transplant. |
Short- and Long-Term Outcomes among a National Cohort of U.S. Veterans Hospitalized for Alcohol-Associated Hepatitis. Among a national cohort of hospitalized Veterans with AH, ∼25% of patients overall and over one-third with severe AH died within 90-days, respectively. These findings emphasize the importance of effective screening for unhealthy alcohol use and prompt linkage to alcohol treatment resources in Veterans to curb this rising epidemic of ALD in this vulnerable population. |
The Magnetic Flexible Endoscope: Phase 1 First-in-Human Clinical Trial. The MFE successfully traversed the human colon without adverse event or patient discomfort. System performance was successful without unanticipated events. This is the first time safety and tolerability of the novel platform has been demonstrated in vivo. ClinicalTrials.gov (NCT05833789). |
Traditional serrated adenomas associated with risk of subsequent high-risk polyps and colorectal cancer. Patients with TSA removal had an elevated risk of colorectal neoplasia, particularly within three years following TSA removal, supporting the current U.S. recommendations for a surveillance colonoscopy at three years. |
| Clin Gastroenterol Hepatol |
Diagnostic Accuracy of Non-Invasive Biomarkers and Imaging for Evaluating Postoperative Recurrence in Crohn's Disease. The high sensitivity of fecal calprotectin (< 50 μg/g) and cross-sectional imaging can help reduce the need for invasive and costly colonoscopy monitoring for CD recurrence after surgery. Applying optimal definitions of sonographic recurrence by IUS parameters may further improve specificity for making therapeutic decisions without endoscopy. |
Janus kinase (JAK) inhibitor-induced acne in inflammatory bowel disease - an international, multicenter, retrospective cohort study. This is the first study characterizing this adverse event in JAK inhibitor-treated IBD patients and presents the largest cohort of JAK inhibitor-induced acne cases across al immune-mediated diseases. Acne is a common adverse effect resulting in significant psychological burden. Early identification, proactive counseling, and timely interventions, such as dose reduction or referral to dermatology, are crucial in managing this side effect. |
Prevalence and Impact of Social Risk in Patients with Inflammatory Bowel Diseases: National Estimates from the United States. Social risks are prevalent in adults with IBD and negatively impact healthcare utilization and medication non-adherence. Efforts to routinely identify and address social risks in patients with IBD should be part of standard clinical care. |
Survival with and without liver transplantation in critically ill patients with cirrhosis: a twenty-year experience. TFS has now plateaued with need for novel interventions to improve survival in ACLF. Liver transplantation is infrequently utilised but has excellent outcomes. ACLF survivors should be closely followed up with strong consideration given for transplant assessment. |
The vasopressin biomarker copeptin is linked to systemic inflammation and refines prognostication in decompensated cirrhosis. In patients with dACLD, copeptin is independently linked to systemic inflammation. The MELD-copeptin score identifies patients with dACLD at risk for impaired clinical outcomes. |
| Endosc Int Open |
Real-time visualization of the gastrointestinal tract during nasogastric tube placement: Pilot study of new video-Assisted system. The video-assisted system provides real-time visualization of the gastrointestinal tract during tube insertion and has been shown to enhance the safety and effectiveness of NG tube placement. |
Transanal endoscopic cooperative surgery as a less invasive resection technique for anorectal tumors extending beyond the dentate line: Case series. No recurrences were recorded at the 17- to 27-month follow-up. TaECS may be a viable treatment for minimally invasive local resection of anorectal tumors extending beyond the dentate line. |
| Endoscopy |
Clinical effectiveness of esophageal stricture dilation using an improved endoscopic attachment cap in adults with eosinophilic esophagitis. Post-dilation pain was recorded in 31.7% (19/60). Esophageal stricture dilation in adults with EoE using the improved endoscopic attachment cap was feasible, clinically effective, and environmentally friendly. |
Diagnostic accuracy of the muscle-retracting sign for determining deep submucosal invasion in early rectal cancer: a prospective observational study. MRS detected using the PDM demonstrated moderate-to-high accuracy in predicting deep SMI in early rectal cancer. This finding may allow the precise selection of an endoscopic resection strategy based on invasion depth for the minimally invasive treatment of early rectal cancer. |
Malignant progression and recurrence rates following endoscopic treatment of gastric hyperplastic polyps. Patients' age (odds ratio[OR] 1.15; 95%CI:1.01-1.36, p=0.040), and polyp size (OR 1.19; 95%CI:1.11-1.30, p The risk of malignant progression in GHPs is low, while local recurrence after endoscopic resection remains notable. Endoscopic treatment should be prioritized for pedunculated polyps ≥20mm, as these are more likely to harbor neoplasia. |
Mechanistic loop resolution strategy for short-type single-balloon enteroscopy-assisted ERCP in patients post Roux-en-Y hepaticojejunostomy with a preserved stomach and duodenum. A standardized mechanistic loop resolution strategy yields high success rates for the short SBE approach and ERCP in patients with a Roux-en-Y hepaticojejunostomy and a preserved stomach and duodenum. |
| Gastroenterology |
Blood-based T Cell Diagnosis of Celiac Disease. Gluten-stimulated IL-2 secretion indicates the presence of pathogenic gluten-specific CD4+ T cells and is a useful diagnostic for CeD. WBAIL-2 and serum IL-2 after gluten could be complementary and allow biopsy-free CeD diagnosis. WBAIL-2 may help diagnose and monitor other CD4+ T cell-driven diseases. |
| Gastrointest Endosc |
Fistula dilation-free endoscopic ultrasound-guided choledochoduodenostomy using tubular dumbbell-shaped metal stent versus endoscopic retrograde cholangiopancreatography in first-line drainage for malignant distal biliary obstruction. Fistula dilation-free EUS-CDS using tubular MS with an appropriate anti-migration function may be a useful option for primary drainage in patients with UMDBO. |
| Gut |
<i>Enterococcus faecalis</i> hijacks FABP2 to activate quorum-sensing signals and aggravate Crohn's disease by inducing gut dysbiosis. This study reveals a novel mechanism by which commensal bacteria use host-derived FABP2 to drive dysbiosis and worsen CD pathology. Targeting the FABP2-EF3041 axis may offer new diagnostic and therapeutic avenues for managing CD. |
Cutting waste in endoscopy: a multicentre observational study in the German healthcare system. The waste generated by endoscopy per year in Germany rivals that of a small town. Adopting targeted waste reduction strategies-focusing on prevention, reduction, reuse, recycling and recovery-can substantially mitigate the environmental footprint of endoscopic practice. |
Histone lactylation-driven feedback loop modulates cholesterol-linked immunosuppression in pancreatic cancer. Our findings highlight the critical role of the H3K18la/ACAT2/sEV-cholesterol axis in TME reprogramming. Targeting this pathway may improve anti-PD-1 therapy response in pancreatic cancer, providing a novel therapeutic strategy by linking histone lactylation, cholesterol metabolic reprogramming and immune modulation. |
NLRP6 deficiency enhances macrophage-mediated phagocytosis via E-Syt1 to inhibit hepatocellular carcinoma progression. Design Immunofluorescence staining was performed in patient samples. Liver tumour models (autonomous, orthotopic, subcutaneous) were developed, and RNA sequencing, flow cytometry and immunohistochemistry were performed in wild-type, -/- macrophages is a promising therapeutic strategy for reducing HCC tumour growth. |
Prophylactic clip closure after endoscopic submucosal dissection of large flat and sessile colorectal polyps: a multicentre randomised controlled trial (EPOC trial). Prophylactic clip closure, successfully achieved in approximately 90% of cases, reduced the delayed bleeding rate after resection of colorectal polyps measuring 20-50 mm. |
| Hepatology |
Arid1a deficiency promotes hepatocyte hyperpolyploidy and drives intrahepatic cholangiocarcinoma in mice. Hepatocytes can transform into ICC through a process involving hyperpolyploidizaiton. This study offers new insights into the pathogenesis of ICC, particularly in patients harboring frequent ARID1A mutations. |
Serum amyloid A1-Induced intrahepatic regulatory T cell dysfunction drives autoimmune hepatitis progression. Intrahepatic Tregs exhibit a diminished suppressive phenotype and an enhanced effector phenotype, failing to control the escalating inflammation in AIH. AIH treatment should not only focus on increasing Treg number but also on restoring their functional capacity. |
Social determinants of health influence the risk of cirrhosis: A diverse nationwide cohort study. SDOH factors were strongly associated with the risk of cirrhosis in a diverse nationwide population and explained a high proportion of variability in cirrhosis risk. SDOH should be considered key modifiable risk factors for advanced liver disease. |
The MASTL/YBX1/PAK4 axis regulated by stress-activated STK24 triggers lenvatinib resistance and tumor progression in hepatocellular carcinoma. We propose that the MASTL/YBX1/PAK4 axis, which is activated by stress-induced STK24, plays a crucial role in lenvatinib tolerance. Inhibiting this axis by targeting MASTL effectively overcomes lenvatinib resistance in HCC. |
Tumor microenvironment heterogeneity and progression mechanisms in intrahepatic cholangiocarcinoma: A study based on single-cell and spatial transcriptomic sequencing. The TME of ICC was heterogeneous. ASPH markedly enhanced ICC invasion The ASPH inhibitor CEP significantly inhibits ICC progression and may serve as a targeted therapeutic drug for ICC. Tumor cells in N1 lymph nodes demonstrate high expression of tumor-specific MHC-II molecules, but silencing of co-stimulatory factors such as CD80/CD86 induces CD4+ T cells into an anergic state. Our study indicated that ASPH and MHC-II may serve as novel therapeutic targets for ICC. |
| J Hepatol |
Association of candidate surrogate endpoints with overall survival in advanced biliary tract cancer. PFS shows a moderate correlation with OS both at the trial- and patient-level, while ORR and DCR show a low correlation. Whilst PFS is currently the best candidate surrogate marker for OS, our results highlight the need for novel endpoints in this field. Impact and implications The use of validated surrogate endpoints in biliary tract cancer trials may decrease costs and improve study feasibility, particularly with agents that only target small subsets of patients or in trials that incorporate a cross-over design. A formal statistical validation of surrogacy requires patient-level and trial-level data. This is the first comprehensive analysis to incorporate novel agents (including immunotherapies and targeted agents), include patient-level data and rigorously and homogeneously extract appropriate measures of treatment effect for endpoint correlation. These results show a moderate correlation for progression-free survival both at the trial- and patient-level and a low correlation for disease-control rate and response rate. This information will aid clinicians in appropriately interpreting contemporary clinical trials and guide clinical researchers and trial sponsors involved in clinical trial design. Furthermore, it has important implications for the regulatory approval process and may aid agencies in appropriately evaluating novel drugs. |
Dissecting metabolic dysfunction- and alcohol-associated liver disease (MetALD) using proteomic and metabolomic profiles. This study emphasizes the importance of subtyping differentiation using proteome data for personalized treatment and improved prognostic outcomes in MetALD patients. |
Steatotic liver disease induces YAP/TAZ-driven cell competition that can suppress tumor initiation. These findings reveal that steatotic hepatocytes in early MASLD can activate endogenous cell competition programs to suppress tumor initiation, a process that depends on Yap/Taz activity. This adds a new layer to our understanding of how fitness landscapes and cell-to-cell interactions within the tissue microenvironment shape cancer risk. It also shows that progression of chronic liver disease not only promotes tumorigenesis through effects of inflammation and fibrosis on tumor cells but also by disrupting the competitive defenses of normal surrounding cells. Impact and implications We found that early stages of steatotic liver disease (MASLD) can suppress tumor initiation in mouse models of liver cancer by triggering Yap/Taz-mediated cell competition. This reveals an unexpected tumor-suppressive role for early MASLD and highlights the importance of non-cell autonomous mechanisms during tumor initiation. Since Hippo-YAP/TAZ signaling is deregulated in many cancers, similar cell competition-based mechanisms may operate in other tissues. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Aliment Pharmacol Ther |
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| Clin Gastroenterol Hepatol |
Novel Noninvasive Tests for Liver Fibrosis: Moving Beyond Simple Tests in Metabolic Dysfunction Associated Steatotic Liver Disease. NILDAs are effective alternatives to liver biopsy for fibrosis assessment in MASLD and may serve as a tool to identify patients who are candidates for newer therapies. |
| Gastroenterology |
In Our Scope of Practice: Genetic Risk Assessment and Testing for GI Cancers and Polyposis in Gastroenterology. Barriers for integration of genetic testing in routine practice include lack of awareness about genetic conditions by patients and providers, concerns about genetic testing costs and implications for insurability, as well as challenges in implementing algorithms for risk assessment and coordinated care in complex medical systems. This review addresses current evidence and guidelines for cancer risk assessment, genetic testing and management to enable GI clinicians to identify and care for individuals with genetic cancer-predisposition syndromes in routine practice. |
Role of non-invasive imaging in the diagnosis and management of patients with suspected and established IBD. The readers will come away with an understanding of what imaging they should consider for different clinical situations and the strengths and limitations of each modality. Future developments of non-invasive diagnostic strategies and areas in need of further research are highlighted. |
| Gut |
Adherent-invasive <i>Escherichia coli</i> in Crohn's disease: the 25th anniversary. In November 2023, prominent members of the AIEC research community met to present and discuss the many facets of basic, translational and clinical AIEC fields at 'AIEC: past, present and future' in NYC. This review is a summary of this international meeting highlighting the history of AIEC, knowledge accumulated over the past 25 years about its pathogenic properties and proposes a standardised approach for screening patients for AIEC. |
Heterogeneity and plasticity of cholangiocytes in liver injury: a journey from pathophysiology to therapeutic utility. A comprehensive understanding of the biological characteristics of cholangiocytes provides insights into developing cholangiocyte cell therapy for cholangiopathies. In this review, we discuss the critical role of cholangiocytes in liver injury and regeneration, reveal the underlying mechanism of cholangiocyte plasticity, and explore the prospects and challenges of using cholangiocytes as a source for cell therapy. |
| J Hepatol |
misc publications eg case reports, tools of the trade, images of the month, etc…
| Am J Gastroenterol |
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| Clin Gastroenterol Hepatol |
| Endosc Int Open |
| Endoscopy |
| Gastroenterology |
| Gastrointest Endosc |
| Gut |
| Hepatology |
| J Hepatol |
Letters to the editors and authors’ replies
| Aliment Pharmacol Ther |
|---|
| Gastroenterology |
| Gut |
| J Hepatol |